Pixantrone - CISMeF

Preferred Label : Pixantrone;

NCIt synonyms : 6,9-Bis((2-aminoethyl)amino)benzo(g)isoquinoline-5,10-dione;

NCIt definition : A synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitumor antibiotics.;

UNII : F5SXN2KNMR;

InChIKey : PEZPMAYDXJQYRV-UHFFFAOYSA-N;

CAS number : 144510-96-3;

Chemical formula : C17H19N5O2;

Codes from synonyms : CDR0000322231; 406;

Details

Origin ID

C26663;

UMLS CUI

C0253355;

CISMeF manual mappings
- Pixantrone (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pixantrone (substance) [SNOMED CT concept]
- pixantrone [ATC Code]
- pixantrone [MeSH concept]
- pixantrone [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- pixantrone [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Pixantrone Dimaleate [NCIt concept]
has_target
- DNA Topoisomerase 2-Alpha [NCIt concept]
is_component_of_chemotherapy_regimen
- Cisplatin/Cytarabine/Methylprednisolone/Pixantrone [NCIt concept]
- Cisplatin/Cytarabine/Methylprednisolone/Pixantrone/Rituximab [NCIt concept]
- Dexamethasone/Fludarabine/Pixantrone/Rituximab [NCIt concept]
- Pixantrone/Rituximab [NCIt concept]
is_free_acid_or_base_form_of
- Pixantrone Dimaleate [NCIt concept]

Keyword's position in hierarchy(ies) :

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