Pixantrone Dimaleate

Preferred Label : Pixantrone Dimaleate;

NCIt synonyms : Pixantrone Maleate; 6,9-Bis((2-Aminoethyl)Amino)Benzo(g)Isoquinoline-5,10-Dione (2z)-But-2-Enedioate (1:2); Benz(g)Isoquinoline-5,10-Dione, 6,9-Bis((2-Aminoethyl)Amino)-, (2z)-2-Butenedioate (1:2);

NCIt related terms : BBR 2778;

NCIt definition : The dimaleate salt of a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitumor antibiotics.;

UNII : P0R64C4CR9;

InChIKey : SVAGFBGXEWPNJC-SPIKMXEPSA-N;

CAS number : 144675-97-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 144675-97-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Pixuvri;

Molecule name : BBR 2778;

Chemical formula : C17H19N5O2.2C4H4O4;

NCI Metathesaurus CUI : CL408667;

Codes from synonyms : CDR0000322132;

Details

Origin ID

C82398;

UMLS CUI

C2826149;

CISMeF manual mappings
- Pixantrone Dimaleate [International Nonproprietary Name]
Manual NTBT mappings (CISMeF)
- Pixantrone (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pixantrone Dimaleate [International Nonproprietary Name]
Validated automatic mappings to NTBT
- pixantrone [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Pixantrone [NCIt concept]
has_target
- DNA Topoisomerase 2-Alpha [NCIt concept]
is_salt_form_of
- Pixantrone [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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