caspase 8 - CISMeF

Preferred Label : caspase 8;

MeSH definition : A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.;

MeSH synonym : mach protein; Mch5 Protease; flice protein; CAP4 Protease; Caspase-8;

MeSH hyponym : Procaspase-8; Procaspase 8; Pro-Caspase-8; Pro Caspase 8;

Registry Number MeSH : EC 3.4.22.-;

Wikipedia link : https://en.wikipedia.org/wiki/Caspase 8;

Is substance : O;

Details

Origin ID

D053181;

UMLS CUI

C0667830;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Caspase-8 [NCIt concept]
Record concept(s)
- Procaspase-8 [MeSH concept]
- caspase 8 [MeSH concept]
Related MeSH Supplementary Concept(s)
- CASP8 protein, human [MeSH Supplementary Concept]
- Casp8 protein, mouse [MeSH Supplementary Concept]
- Casp8 protein, rat [MeSH Supplementary Concept]
Related MeSH term(s)
- alstrom syndrome [MeSH Descriptor]
- caspase inhibitors [MeSH Descriptor]
See also
- autoimmune lymphoproliferative syndrome [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Caspase-8 [NCIt concept]

Keyword's position in hierarchy(ies) :

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