caspases - CISMeF

Preferred Label : caspases;

MeSH definition : A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.;

MeSH synonym : Caspase;

Registry Number MeSH : EC 3.4.22.-;

MeSH annotation : CASPASES, EFFECTOR and CASPASES, INITIATOR and specifics are available;

Wikipedia link : https://en.wikipedia.org/wiki/Caspase;

Is substance : O;

Details

Origin ID

D020169;

UMLS CUI

C0010656;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Caspase-2 [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-5 [NCIt concept]
- Caspase-6 [NCIt concept]
- Caspase-7 [NCIt concept]
- Caspase-9 [NCIt concept]
- Cathepsin Z [NCIt concept]
- Cysteine Proteinase [NCIt concept]
Currated CISMeF NLP mapping
- Caspase [NCIt concept]
Indexing information
- 3,4-methylenedioxyphenyl 3,4,5--trihydroxythiobenzoate [MeSH Supplementary Concept]
- 3,4-methylenedioxyphenyl 3,4,5-trihydroxybenzoate [MeSH Supplementary Concept]
- Ac-AAVALLPAVLLALLAPYVAD-CHO [MeSH Supplementary Concept]
- BIRC8 protein, human [MeSH Supplementary Concept]
- CV 1013 [MeSH Supplementary Concept]
- IDN 1529 [MeSH Supplementary Concept]
- N-((1,3-dimethylindole-2-carbonyl)-valinyl)-3-amino-4-oxo-5-fluoropentanoic acid [MeSH Supplementary Concept]
- Nol3 protein, mouse [MeSH Supplementary Concept]
- Nol3 protein, rat [MeSH Supplementary Concept]
- Z-Asp-2,6-dichlorobenzoyl-oxymethylketone [MeSH Supplementary Concept]
- acetyl-AAVALLPAVLLALLAP-DEVD-CHO [MeSH Supplementary Concept]
- acetyl-aspartyl-glutamyl-valyl-lysine chloromethyl ketone [MeSH Supplementary Concept]
- acetyl-leucyl-glutamyl-histidyl-aspartal [MeSH Supplementary Concept]
- aposome [MeSH Supplementary Concept]
- xyz 033 mp [MeSH Supplementary Concept]
Record concept(s)
- caspases [MeSH concept]
Related MeSH Supplementary Concept(s)
- CASP14 protein, human [MeSH Supplementary Concept]
- CASP5 protein, human [MeSH Supplementary Concept]
- Casp14 protein, mouse [MeSH Supplementary Concept]
- Casp4 protein, mouse [MeSH Supplementary Concept]
- Casp4 protein, rat [MeSH Supplementary Concept]
- DAMM protein, drosophila [MeSH Supplementary Concept]
- Dcp-1 protein, drosophila [MeSH Supplementary Concept]
- MALT1 protein, human [MeSH Supplementary Concept]
- MC1 protein, arabidopsis [MeSH Supplementary Concept]
- MC2 protein, arabidopsis [MeSH Supplementary Concept]
- MCA1 protein, S cerevisiae [MeSH Supplementary Concept]
- Malt1 protein, mouse [MeSH Supplementary Concept]
- Mca1 protein, S pombe [MeSH Supplementary Concept]
- STRICA protein, Drosophila [MeSH Supplementary Concept]
- caspa protein, zebrafish [MeSH Supplementary Concept]
- caspase 11, human [MeSH Supplementary Concept]
- caspase 13 [MeSH Supplementary Concept]
- caspase 32, rat [MeSH Supplementary Concept]
- caspase 9s, human [MeSH Supplementary Concept]
- caspb protein, zebrafish [MeSH Supplementary Concept]
- ced-3 protein, C elegans [MeSH Supplementary Concept]
- csp-1 protein, C elegans [MeSH Supplementary Concept]
- csp-3 protein, C elegans [MeSH Supplementary Concept]
- decay protein, drosophila [MeSH Supplementary Concept]
- drICE protein, Drosophila [MeSH Supplementary Concept]
- dredd protein, drosophila [MeSH Supplementary Concept]
- dronc protein, Drosophila [MeSH Supplementary Concept]
- metacaspase 9, arabidopsis [MeSH Supplementary Concept]
- type II metacaspase, tomato [MeSH Supplementary Concept]
Related MeSH term(s)
- caspase inhibitors [MeSH Descriptor]
See also
- apoptosis [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Caspase [NCIt concept]

Keyword's position in hierarchy(ies) :

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