caspase 2 - CISMeF

Preferred Label : caspase 2;

MeSH definition : A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.;

MeSH synonym : ich 1 protease; ich-1 protease; Caspase-2;

MeSH hyponym : caspase 2 subunit p13; caspase 2 subunit p12; caspase 2 subunit p18; Procaspase-2; Procaspase 2; Pro-Caspase-2; Pro Caspase 2;

MeSH Related Number : caspase 2 subunit p18; caspase 2 subunit p12; caspase 2 subunit p13;

Registry Number MeSH : EC 3.4.22.-;

Related CAS MeSH : EC 3.4.22.- (Caspase 2 subunit p18); EC 3.4.22.- (Caspase 2 subunit p12); EC 3.4.22.- (Caspase 2 subunit p13);

Wikipedia link : https://en.wikipedia.org/wiki/Caspase 2;

Is substance : O;

Details

Origin ID

D053143;

UMLS CUI

C0259419;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- CASP2 wt Allele [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-5 [NCIt concept]
- Caspase-6 [NCIt concept]
- Caspase-7 [NCIt concept]
- Caspase-9 [NCIt concept]
- Cathepsin Z [NCIt concept]
- Cysteine Proteinase [NCIt concept]
- caspase 2 [HGNC gene]
Record concept(s)
- Procaspase-2 [MeSH concept]
- caspase 2 [MeSH concept]
- caspase 2 subunit p12 [MeSH concept]
- caspase 2 subunit p13 [MeSH concept]
- caspase 2 subunit p18 [MeSH concept]
Related MeSH Supplementary Concept(s)
- CASP2 protein, human [MeSH Supplementary Concept]
- Casp2 protein, mouse [MeSH Supplementary Concept]
Related MeSH term(s)
- caspase inhibitors [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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