Preferred Label : Death Domain-Associated Protein 6;
NCIt synonyms : ETS1 Associated Protein 1; hDAXX; DAXX; DAXX Protein; Death-Associated Protein 6; EAP1; FAS Death Domain-Associated Protein; Fas-Binding Protein; Death Domain-Associated Protein-6; CENP-C Binding Protein;
NCIt definition : Death domain-associated protein 6 (740 aa, 81 kDa) is encoded by the human DAXX gene.
This protein is involved in the negative regulation of both gene transcription and
protein ubiquitination.;
NCIt note : Death domain-associated protein 6 has NLS, Glu-rich, and JNK activation domains. Bound
to TGFBR2 and TNFRSF6 FAS death domain via its C-terminus, DAXX bridges apoptotic
FAS activation with caspase-independent ASK1 activation of JNK. HSPB1/HSP27-DAXX may
block TNFRSF6/ASK1. DAXX co-represses transcription by recruitment to nucleoli or
PML/POD/ND10 nuclear bodies through interaction with MCSR1 or PML and directly inhibits
PAX3 and ETS1. As part of the PAX5/CREBBP complex, DAXX may modulate PAX5 activity.
DAXX binds to SLC2A4/GLUT4, CENPC1, UBE2I, PAX7, DEK, HDAC1, HDAC2, HDAC3, and histones
H2A, H2B, H3, and H4. (from LocusLink, Swiss-Prot, OMIM, and NCI);
Origin ID : C21260;
UMLS CUI : C0541030;
Currated CISMeF NLP mapping
OMIM relation
Semantic type(s)
UMLS correspondences (same concept)
concept_is_in_subset
gene_encodes_gene_product
gene_product_has_associated_anatomy
gene_product_has_biochemical_function
gene_product_has_organism_source
gene_product_has_structural_domain_or_motif
gene_product_is_element_in_pathway
gene_product_plays_role_in_biological_process