Preferred Label : Anti-CD40 Agonistic Monoclonal Antibody LNF1901;
NCIt synonyms : Anti-CD40 Monoclonal Antibody LNF1901; Anti-CD40 Agonist Monoclonal Antibody LNF1901;
NCIt definition : A humanized, agonistic monoclonal antibody targeting the B-cell surface antigen CD40,
with potential immunostimulatory and antineoplastic activities. Upon administration,
anti-CD40 agonistic monoclonal antibody LNF1901 targets and binds to CD40 on a variety
of immune cell types. This induces CD40-dependent signaling pathways, triggers the
proliferation and activation of antigen-presenting cells (APCs) and activates T-cells.
This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response
against tumor cells. CD40, a cell surface receptor and member of the tumor necrosis
factor receptor superfamily (TNFRSF), is expressed on various immune cells, such as
dendritic cells (DCs), macrophages and B-cells, and plays a key role in the activation
of the immune system.;
Molecule name : LNF-1901; LNF 1901;
Origin ID : C207268;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
