" /> Dacetuzumab - CISMeF





Preferred Label : Dacetuzumab;

NCIt synonyms : Anti-huCD40 mAb; Monoclonal Antibody SGN-40;

NCIt related terms : SGN-40;

NCIt definition : A humanized monoclonal antibody directed against the CD40 receptor with potential antineoplastic activity. Dacetuzumab specifically binds to and inhibits the CD40 receptor, thereby inducing apoptosis and inhibiting cellular proliferation via antibody-dependent cellular cytotoxicity (ADCC) in cells that overexpress this receptor. The CD40 receptor, a member of the tumor necrosis factor (TNF) receptor super-family, is highly expressed on most B lineage hematologic malignancies including multiple myeloma, non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Hodgkin's disease and acute lymphoblastic leukemia.;

Alternative definition : NCI-GLOSS: A monoclonal antibody that binds to cells that have the CD40 antigen on their surface, including cells from multiple myeloma, non-Hodgkin lymphoma, and chronic lymphocytic leukemia. SGN-40 is being studied in the treatment of cancer. It is a type of monoclonal antibody.;

UNII : UT59FF4T5X;

CAS number : 880486-59-9;

Molecule name : SGN-40; huS2C6;

Codes from synonyms : CDR0000405813;

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30/05/2025


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