Dacetuzumab - CISMeF

Preferred Label : Dacetuzumab;

NCIt synonyms : Anti-huCD40 mAb; Monoclonal Antibody SGN-40;

NCIt related terms : SGN-40;

NCIt definition : A humanized monoclonal antibody directed against the CD40 receptor with potential antineoplastic activity. Dacetuzumab specifically binds to and inhibits the CD40 receptor, thereby inducing apoptosis and inhibiting cellular proliferation via antibody-dependent cellular cytotoxicity (ADCC) in cells that overexpress this receptor. The CD40 receptor, a member of the tumor necrosis factor (TNF) receptor super-family, is highly expressed on most B lineage hematologic malignancies including multiple myeloma, non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Hodgkin's disease and acute lymphoblastic leukemia.;

Alternative definition : NCI-GLOSS: A monoclonal antibody that binds to cells that have the CD40 antigen on their surface, including cells from multiple myeloma, non-Hodgkin lymphoma, and chronic lymphocytic leukemia. SGN-40 is being studied in the treatment of cancer. It is a type of monoclonal antibody.;

UNII : UT59FF4T5X;

CAS number : 880486-59-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 880486-59-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : SGN-40; huS2C6;

Codes from synonyms : CDR0000405813;

Details

Origin ID

C62179;

UMLS CUI

C2742509;

Currated CISMeF NLP mapping
- dacetuzumab [MeSH concept]
- dacetuzumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- dacetuzumab [MeSH Supplementary Concept]
- dacetuzumab [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Receptor Superfamily Member 5 [NCIt concept]

Keyword's position in hierarchy(ies) :

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