NCIt definition : A humanized monoclonal antibody directed against the CD40 receptor with potential
antineoplastic activity. Dacetuzumab specifically binds to and inhibits the CD40 receptor,
thereby inducing apoptosis and inhibiting cellular proliferation via antibody-dependent
cellular cytotoxicity (ADCC) in cells that overexpress this receptor. The CD40 receptor,
a member of the tumor necrosis factor (TNF) receptor super-family, is highly expressed
on most B lineage hematologic malignancies including multiple myeloma, non-Hodgkin's
lymphoma, chronic lymphocytic leukemia, Hodgkin's disease and acute lymphoblastic
leukemia.;
Alternative definition : NCI-GLOSS: A monoclonal antibody that binds to cells that have the CD40 antigen on
their surface, including cells from multiple myeloma, non-Hodgkin lymphoma, and chronic
lymphocytic leukemia. SGN-40 is being studied in the treatment of cancer. It is a
type of monoclonal antibody.;