NCIt definition : A fully human immunoglobulin G2 (IgG2) agonistic monoclonal antibody targeting the
B-cell surface antigen CD40, with potential immunostimulatory and antineoplastic activities.
Upon administration, CDX-1140 targets and binds to CD40 on a variety of immune cell
types. This induces CD40-dependent signaling pathways, triggers the proliferation
and activation of antigen-presenting cells (APCs) and activates T-cells. This results
in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor
cells. CD40, a cell surface receptor and member of the tumor necrosis factor receptor
superfamily (TNFRSF), is expressed on various immune cells, such as dendritic cells
(DCs), macrophages and B-cells, and plays a key role in the activation of the immune
system.;
Semantic type(s)