Preferred Label : Anti-CD40/Anti-mesothelin Bispecific Antibody ABBV-428;
NCIt synonyms : Anti-CD40 x Anti-mesothelin Bispecific Antibody ABBV-428; Anti-CD40/Anti-MSLN Bispecific Antibody ABBV-428;
NCIt definition : A bispecific antibody directed against both the cell-surface receptor CD40 and the
tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunostimulatory
and antineoplastic activities. Upon administration of anti-CD40/anti-MSLN bispecific
antibody ABBV-428, the anti-MSLN moiety targets and binds to MSLN expressed on tumor
cells. The agonistic anti-CD40 moiety targets and binds to various CD40-expressing
immune cells in the tumor microenvironment (TME) and induces CD40-dependent signaling
pathways, which triggers the proliferation and activation of antigen-presenting cells
(APCs) and activates T-cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated
immune response against tumor cells. CD40, a stimulatory receptor and a member of
the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune
cells, such as macrophages, B-lymphocytes, and dendritic cells (DCs); it plays a key
role in the activation of the immune system. MSLN, a cell surface glycoprotein involved
in cell adhesion, is overexpressed in a variety of cancer cell types.;
Molecule name : ABBV 428; ABBV-428;
NCI Metathesaurus CUI : CL520571;
Origin ID : C132681;
UMLS CUI : C4329316;
Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
