" /> Mesothelin - CISMeF





Preferred Label : Mesothelin;

NCIt synonyms : MSLN; Pre-Pro-Megakaryocyte-Potentiating Factor; CAK1 Antigen;

NCIt definition : Mesothelin (630 aa, 69 kDa) is encoded by the human MSLN gene. This protein may play a role in cellular adhesion.;

Alternative definition : NCI-GLOSS: A protein found on the surface of certain types of normal cells and cancer cells. Mesothelin may help these cells stick together and send signals. A higher-than-normal amount of mesothelin is found on some cancer cells, including mesothelioma, pancreatic cancer, and ovarian cancer.;

NCIt note : An antibody that reacts with ovarian cancers and mesotheliomas was used to isolate a cell surface antigen named mesothelin. Although the function of mesothelin is unknown, it may play a role in cellular adhesion and is present on mesothelium, mesotheliomas, and ovarian cancers. Three transcript variants have been described for this gene and their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. The protein isoform named MPF is a cytokine with megakaryocyte potentiating activity. The soluble member encoded by the third splice variant is detected in ovarian carcinoma; the full length sequence of the third variant has not been described. (LocusLink);

Codes from synonyms : CDR0000527376;

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15/05/2024


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