Anti-mesothelin CIR mRNA-electroporated Autologous T Cells - CISMeF
Anti-mesothelin CIR mRNA-electroporated Autologous T CellsNCIt concept
Preferred Label : Anti-mesothelin CIR mRNA-electroporated Autologous T Cells;
NCIt synonyms : Autologous Redirected RNA Meso-CIR T cells;
NCIt definition : Autologous chimeric immune receptor (CIR) T cells transfected with anti-mesothelin
chimeric T cell receptor mRNA, with potential antineoplastic activity. The anti-mesothelin
mRNA encodes a single chain antibody variable fragment (ScFv), the intracellular CD
3 zeta T cell receptor domain and the 4-1BB (cd137) costimulatory domain. Upon intravenous
administration, the anti-mesothelin CIR mRNA-electroporated autologous T cells may
attach to cancer cells expressing mesothelin. This may stimulate the secretion of
multiple cytokines and may result in cell lysis of mesothelin-expressing cancer cells.
Mesothelin is a cell surface glycoprotein involved in cell adhesion and is overexpressed
in many epithelial-derived cancers.;