" /> Gavocabtagene Autoleucel - CISMeF





Preferred Label : Gavocabtagene Autoleucel;

NCIt synonyms : Autologous Anti-mesothelin TRuC T-cells TC-210; Gavo-cel; Autologous Anti-mesothelin T-cell Receptor Fusion Construct T-cells TC-210; TC-210 T Cells;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically engineered to express a single-domain antibody that recognizes human mesothelin, fused to the N-terminus of the CD3-epsilon T-cell receptor (TCR) subunit which, upon expression is incorporated into the endogenous TCR complex, with potential antineoplastic activity. Upon administration, gavocabtagene autoleucel specifically target and bind to mesothelin-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types. Compared to chimeric antigen receptor (CAR) T-cells, TRuCs may be associated with less pro-inflammatory cytokine secretion and fewer adverse effects without compromising therapeutic efficacy.;

UNII : NP6CFH3G8H;

Molecule name : TC 210; TC-210;

NCI Metathesaurus CUI : CL969765;

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10/05/2024


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