Preferred Label : Live-Attenuated Listeria Encoding Human Mesothelin Vaccine CRS-207;
NCIt synonyms : LADD Listeria monocytogenes CRS-207;
NCIt related terms : CRS-207;
NCIt definition : A recombinant Listeria-based cancer vaccine containing a live-attenuated strain of
the facultative intracellular bacterium Listeria monocytogenes (Lm) expressing human
mesothelin with potential immunostimulatory and antineoplastic activities. Upon administration
of this vaccine, Listeria invade professional phagocytes within the immune system
and express mesothelin, which may activate a cytotoxic T-lymphocyte (CTL) response
against mesothelin-expressing tumor cells, resulting in tumor cell lysis. In addition,
the Listeria vector itself may induce a potent innate and adaptive immunity unrelated
to mesothelin expression. Mesothelin is a cell surface glycoprotein involved in cell
adhesion and is overexpressed in many epithelial-derived cancers, including pancreatic,
ovarian and lung cancers, and malignant mesotheliomas.;
UNII : JJX4JHS4PO;
Molecule name : CRS-207;
NCI Metathesaurus CUI : CL383482;
Origin ID : C74055;
UMLS CUI : C2346687;
Semantic type(s)
- concept_is_in_subset
- has_target
