Autologous Anti-mesothelin CAR-IL-7-CCL19-expressing T-lymphocytes TAK-103

Preferred Label : Autologous Anti-mesothelin CAR-IL-7-CCL19-expressing T-lymphocytes TAK-103;

NCIt synonyms : Autologous Anti-MSLN CAR T-cells TAK-103; CAR T Cells TAK-103; Autologous Anti-mesothelin CAR-T Cells TAK-103;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN) and simultaneously produce interleukin-7 (IL-7) and C-C motif chemokine 19 (CCL19), with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion and reintroduction into the patient, the autologous anti-MSLN CAR-T cells TAK-103 specifically target and kill MSLN-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types. IL-7 promotes the proliferation and survival of T-cells. CCL19 enhances the migration of T-cells and dendritic cells (DCs).;

Molecule name : TAK 103; NIB 103; TAK-103; NIB-103;

NCI Metathesaurus CUI : CL1773943;

Details

Origin ID

C185598;

UMLS CUI

C5667010;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Mesothelin [NCIt concept]

Keyword's position in hierarchy(ies) :

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