NCIt definition : A preparation of autologous T-lymphocytes transduced with a lentiviral vector expressing
a chimeric antigen receptor (CAR) consisting of an anti-mesothelin M5 single chain
variable fragment (scFv) fused to the costimulatory domains of 4-1BB (CD137) and the
zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating
and antineoplastic activities. After isolation, transduction, expansion in culture
and reintroduction into the patient, the autologous anti-mesothelin CAR-CD3zeta-4-1BB-expressing
T-cells specifically target and induce selective toxicity in mesothelin-expressing
tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is
overexpressed in a variety of cancer cell types.;