Preferred Label : Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11;
NCIt synonyms : Anti-mesothelin mRNA-transfected Autologous PBMCs MCY-M11;
NCIt related terms : MCY-M11;
NCIt definition : Autologous peripheral blood mononuclear cells (PBMCs) transfected with anti-mesothelin
chimeric antigen receptor (CAR) mRNA, with potential antineoplastic activity. Upon
intraperitoneal (IP) administration, the autologous mesothelin-specific human mRNA
CAR-transfected PBMCs MCY-M11 recognize, bind to, phagocytose and directly kill cancer
cells expressing mesothelin. In addition, MCY-M11 stimulates the immune system to
induce a cytotoxic T-lymphocyte response against the mesothelin-expressing cancer
cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed
in many epithelial-derived cancers.;
UNII : ER09HM7LIR;
Molecule name : MCY-M11;
NCI Metathesaurus CUI : CL556250;
Origin ID : C155775;
UMLS CUI : C4733654;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
