Anti-mesothelin iCasp9M28z CAR-transduced Autologous T Lymphocytes - CISMeF
Anti-mesothelin iCasp9M28z CAR-transduced Autologous T LymphocytesNCIt concept
Preferred Label : Anti-mesothelin iCasp9M28z CAR-transduced Autologous T Lymphocytes;
NCIt synonyms : iCasp9M28z T Cells;
NCIt definition : Genetically modified, autologous T-lymphocytes transduced with a retroviral vector
encoding a chimeric antigen receptor (CAR) specific for mesothelin linked to the signaling
domains for the co-stimulatory molecules CD28 and CD3 zeta, as well as the suicide
gene inducible caspase 9 (iCasp9 or iC9), with potential immunomodulating and antineoplastic
activities. Upon intravenous administration, anti-mesothelin iCasp9M28z CAR-transduced
autologous T lymphocytes specifically target and kill mesothelin-expressing tumor
cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation
(FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable
side effects, a dimerizing agent can be administered, which binds to the FKBP12-F36V
drug-binding domain and activates caspase 9, resulting in the apoptosis of the administered
T-cells. Mesothelin, a tumor-associated antigen, is overexpressed in a variety of
cancer cell types.;