Preferred Label : Anti-mesothelin Antibody-drug Conjugate SGN-MesoC2;
NCIt synonyms : ADC SGN-MesoC2; Anti-MSLN ADC HBM9033; Anti-MSLN ADC SGN-MesoC2; Anti-MSLN/TOP1i ADC SGN-MesoC2;
NCIt definition : An antibody-drug conjugate (ADC) composed of a human monoclonal antibody directed
against the cell surface glycoprotein and tumor-associated antigen (TAA) mesothelin
(MSLN) and conjugated, via a tumor-specific cleavable linker, to a topoisomerase-1
inhibitor (TOP1i), with potential antineoplastic activity. Upon administration of
anti-MSLN ADC SGN-MesoC2, the monoclonal antibody moiety targets and binds to MSLN-expressing
tumor cells. Upon binding, internalization and linker cleavage, the TOP1i is released,
and inhibits DNA topoisomerase-1 activity, thereby inhibiting DNA replication and
resulting in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation
of MSLN-expressing tumor cells. MSLN is overexpressed by all mesotheliomas and a variety
of other cancers, while it is minimally expressed in normal tissue.;
Molecule name : HBM 9033; HBM-9033; PF-08052666; SGN-MesoC2; SGN MesoC2; PF 08052666; YL-215; YL 215;
Origin ID : C210446;
concept_is_in_subset
- has_target
