Preferred Label : Autologous Anti-mesothelin T-cell Receptor Fusion Construct/PD-1:CD28 Switch Receptor-expressing
T-cells TC-510;
NCIt synonyms : Autologous Anti-MSLN TCR Fusion Construct/PD-1:CD28 Switch Receptor-expressing T-cells
TC-510; Autologous Anti-mesothelin PD-1:CD28 Switch Receptor-expressing TRuC-T Cells TC-510;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically engineered to
express a single-domain antibody that recognizes human tumor-associated antigen (TAA)
mesothelin (MSLN), fused to the N-terminus of the CD3-epsilon T-cell receptor (TCR)
subunit which, upon expression is incorporated into the endogenous TCR complex, and
a PD-1:CD28 switch receptor composed of the extracellular ligand binding domain of
the human inhibitory receptor programmed cell death protein 1 (PD-1; PDCD1) fused
to the transmembrane and cytoplasmic co-stimulatory signaling domains of CD28, with
potential immunomodulating and antineoplastic activities. Upon reintroduction into
the patient, autologous anti-MSLN TCR fusion construct/PD-1:CD28 switch receptor-expressing
T-cells TC-510 specifically target and bind to MSLN-expressing tumor cells. This leads
to T-cell activation and T-cell mediated lysis of MSLN-expressing tumor cells. The
switch receptor expressed by the engineered T-cells TC-510 targets and binds to the
PD-1 ligands, programmed cell death ligand 1 (PD-L1) and 2 (PD-L2), expressed on tumor
cells. The nature of the PD-1/CD28 switch receptor fusion protein prevents the normal
PD1/PD-L1-mediated T-cell suppression and, instead, promotes signaling through the
CD28 domain, which results in the stimulation of T-lymphocytes. This induces enhanced
toxicity against tumor cells. Mesothelin, a cell surface glycoprotein involved in
cell adhesion, is overexpressed in a variety of cancer cell types.;
Molecule name : TC-510; TC 510;
NCI Metathesaurus CUI : CL1794069;
Origin ID : C188805;
UMLS CUI : C5706514;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
