Preferred Label : Anti-mesothelin/MMAE Antibody-Drug Conjugate DMOT4039A;
NCIt definition : An antibody-drug conjugate (ADC) composed of MMOT0530A, a humanized immunoglobulin
(Ig) G1 monoclonal antibody directed against the cell surface glycoprotein mesothelin
(MSLN), and covalently linked, via a protease-cleavable peptide linker, to monomethyl
auristatin E (MMAE), an auristatin derivative and a potent microtubule disrupting
agent, with potential antineoplastic activity. Upon administration, the monoclonal
antibody moiety of DMOT4039A binds to MSLN-expressing tumor cells and is internalized,
thereby delivering MMAE intracellularly. Proteolytic cleavage releases MMAE, which
then binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest
and tumor cell apoptosis. MSLN, a tumor-associated antigen (TAA), is overexpressed
by all mesotheliomas and a variety of other cancers, while it is minimally expressed
in normal tissue.;
Molecule name : RG7600; RG 7600; DMOT-4039A;
NCI Metathesaurus CUI : CL433928;
Origin ID : C116746;
UMLS CUI : C3896875;
Semantic type(s)
- concept_is_in_subset
- has_target
