Preferred Label : Anti-MSLN CAR-T Cells LCAR-M23;
NCIt synonyms : Mesothelin-targeting CAR T Cells LCAR-M23; Anti-mesothelin CAR T-cells LCAR-M23;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin
(MSLN), with potential immunomodulating and antineoplastic activities. Upon administration,
the anti-MSLN CAR-T cells LCAR-M23 specifically target and kill MSLN-expressing tumor
cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed
in a variety of cancer cell types.;
Molecule name : LCAR-M23; LCAR M23;
NCI Metathesaurus CUI : CL1648141;
Origin ID : C178439;
UMLS CUI : C5555034;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
