Preferred Label : Anti-mesothelin CAR-CD40L-expressing T-lymphocytes;
NCIt synonyms : Anti-MSLN CAR-CD40L-expressing T-cells; CD40 Ligand Expressing MSLN-CAR T Cells; Anti-MSLN CAR-CD40L-expressing T-lymphocytes;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin
(MSLN), and CD40 ligand (CD40L; CD154; TRAP; TNFSF5), with potential immunomodulating
and antineoplastic activities. Upon administration, anti-MSLN CAR-CD40L-expressing
T-lymphocytes specifically target and kill MSLN-expressing tumor cells. Mesothelin,
a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety
of cancer cell types. CD40L binds to CD40 and activates CD40/CD40L-mediated signaling,
which activates monocyte-derived dendritic cells (moDCs), increases the secretion
of inflammatory cytokines and further stimulates cytotoxic T-lymphocytes (CTLs). This
enhances cytotoxicity and anti-tumor immune response.;
NCI Metathesaurus CUI : CL1907035;
Origin ID : C200193;
UMLS CUI : C5856157;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
