" /> Autologous Anti-mesothelin KIR-CAR-transduced T-cells SynKIR-110 - CISMeF





Preferred Label : Autologous Anti-mesothelin KIR-CAR-transduced T-cells SynKIR-110;

NCIt synonyms : Autologous Anti-MSLN KIR-CAR-transduced T-cells SynKIR-110; Autologous Anti-mesothelin KIR-CAR-expressing T-cells SynKIR-110;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a killer cell immunoglobulin-like receptor (KIR)-based chimeric antigen receptor (CAR) consisting of an anti-mesothelin (MSLN) single chain variable fragment (scFv) fused to the transmembrane and cytoplasmic domains of the stimulatory KIR 2DS2 (KIR2DS2), and the immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor protein and costimulatory chain DAP12, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-MSLN KIR-CAR-transduced T-cells SynKIR-110 specifically target and kill MSLN-expressing tumor cells. Mesothelin, a tumor-associated antigen (TAA) and cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types. KIR is normally expressed by natural killer (NK) cells, and KIR-based CAR may decrease T-cell exhaustion and enhance T-cell persistence.;

Molecule name : SynKIR 110; SynKIR-110;

NCI Metathesaurus CUI : CL1912596;

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12/05/2024


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