Autologous Anti-mesothelin TCR-expressing T-cells FH-TCR TMSLN

Preferred Label : Autologous Anti-mesothelin TCR-expressing T-cells FH-TCR TMSLN;

NCIt synonyms : FH-TCR TMSLN; Autologous Mesothelin-specific TCR T-cells FH-TCR TMSLN; Autologous Transgenic T-cells Expressing Mesothelin-specific T-cell Receptor FH-TCR TMSLN; Autologous Mesothelin-specific TCR-expressing T-cells FH-TCR TMSLN;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) human mesothelin (TMSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-mesothelin TCR-expressing T-cells FH-TCR TMSLN specifically target and bind to mesothelin-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types.;

NCI Metathesaurus CUI : CL1412970;

Details

Origin ID

C175659;

UMLS CUI

C5446661;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Mesothelin [NCIt concept]

Keyword's position in hierarchy(ies) :

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