Preferred Label : Anti-mesothelin T-cell Engaging Bispecific Antibody JNJ-79032421;
NCIt synonyms : Anti-MSLN T-cell Engager JNJ-79032421; Anti-MSLN TCE JNJ-79032421; Anti-mesothelin/Anti-CD3 Bispecific Antibody JNJ-79032421;
NCIt definition : A bispecific T-cell engager (TCE) and bispecific antibody directed against both the
tumor-associated antigen (TAA) mesothelin (MSLN) and the T-cell surface antigen CD3,
with potential immunostimulating and antineoplastic activities. Upon administration,
anti-mesothelin T-cell engaging bispecific antibody JNJ-79032421 targets and binds
to MSLN expressed on tumor cells and to CD3 expressed on cytotoxic T-lymphocytes (CTLs).
This activates and redirects CTLs to MSLN-expressing tumor cells, which results in
the CTL-mediated death of MSLN-expressing tumor cells. MSLN, a cell surface glycoprotein
involved in cell adhesion, is overexpressed in a variety of cancer cell types.;
Molecule name : JNJ-2421; JNJ-79032421; JNJ 79032421;
Origin ID : C209760;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
