Preferred Label : Anti-MSLN/Anti-CD3 Bispecific Antibody ZW171;
NCIt synonyms : TCE ZW171; MSLN-targeting T-cell Engager ZW171; Anti-mesothelin/Anti-CD3 Bispecific Antibody ZW171; Anti-MSLN/CD3 T-cell Engaging Bispecific Antibody ZW171; MSLN x CD3 2 1 Bispecific Antibody ZW171;
NCIt definition : A bispecific T-cell engager (TCE) and bispecific antibody directed against both the
tumor-associated antigen (TAA) mesothelin (MSLN) and the T-cell surface antigen CD3,
with potential immunostimulating and antineoplastic activities. Upon administration,
anti-MSLN/anti-CD3 bispecific antibody ZW171 bivalently binds to MSLN expressed on
tumor cells and monovalently binds to CD3 expressed on cytotoxic T-lymphocytes (CTLs).
This activates and redirects CTLs to MSLN-expressing tumor cells, which results in
the CTL-mediated death of MSLN-expressing tumor cells. MSLN, a cell surface glycoprotein
involved in cell adhesion, is overexpressed in a variety of cancer cell types.;
Molecule name : ZW 171; ZW-171;
Origin ID : C210020;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
