Preferred Label : Inezetamab;
NCIt synonyms : Bifunctional Fusion Protein AMG 994; Bispecific Antibody AMG 994;
NCIt definition : A bispecific antibody directed against both the cell-surface receptor CD40 and the
tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunostimulatory
and antineoplastic activities. Upon administration of inezetamab, the anti-MSLN moiety
targets and binds to MSLN expressed on tumor cells. The agonistic anti-CD40 moiety
targets and binds to various CD40-expressing immune cells in the tumor microenvironment
(TME) and induces CD40-dependent signaling pathways, which triggers the proliferation
and activation of antigen-presenting cells (APCs) and activates T-cells. This results
in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response against MSLN-expressing
tumor cells. CD40, a stimulatory receptor and a member of the tumor necrosis factor
receptor superfamily (TNFRSF), is expressed on various immune cells, such as macrophages,
B-lymphocytes, and dendritic cells (DCs); it plays a key role in the activation of
the immune system. MSLN, a cell surface glycoprotein involved in cell adhesion, is
overexpressed in a variety of cancer cell types.;
UNII : DZY93T274S;
CAS number : 2568264-76-4;
Molecule name : AMG994; AMG 994;
NCI Metathesaurus CUI : CL1663044;
Origin ID : C180531;
UMLS CUI : C5706854;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
