Preferred Label : Mesothelin/CD3e Tri-specific T-cell Activating Construct HPN536;
NCIt synonyms : Mesothelin/CD3e-specific TriTAC HPN536; MSLN-specific TriTAC HPN536; Mesothelin-targeting T-cell Engager HPN536; MSLN/CD3e TriTAC HPN536; TriTAC HPN536;
NCIt definition : recombinant antibody derivative composed of a tri-specific T-cell activating construct
(TriTAC) directed against the human tumor-associated antigen (TAA) mesothelin (MSLN)
and the epsilon domain of CD3 antigen (CD3e) found on T-lymphocytes which are both
linked to either side of an anti-albumin single domain antibody, with potential immunostimulating
and antineoplastic activities. Upon administration of the MSLN/CD3e TriTAC HPN536,
the anti-MSLN single antibody domain targets and binds MSLN on tumor cells and the
anti-CD3e single-chain variable fragment (scFv) targets and binds to CD3e on cytotoxic
T-lymphocytes (CTLs), thereby bringing MSLN-expressing tumor cells and CTLs together,
which results in the CTL-mediated cell death of MSLN-expressing tumor cells. The albumin-binding
domain targets and binds to serum albumin, thereby extending the serum half-life of
HPN536. MSLN is overexpressed on the surface of certain tumor cell types. Overexpression
of MSLN is often associated with poor prognosis.;
Molecule name : HPN-536; HPN 536;
NCI Metathesaurus CUI : CL973294;
Origin ID : C162935;
UMLS CUI : C5206864;
Semantic type(s)
- concept_is_in_subset
- has_target
