Preferred Label : Pemlimogene Merolisbac;
NCIt synonyms : JNJ-64041757; LADD Listeria monocytogenes JNJ-64041757;
NCIt definition : A proprietary, live-attenuated, double-deleted (LADD) strain of the Gram-positive
bacterium Listeria monocytogenes (Lm) encoding the tumor-associated antigens (TAAs)
epidermal growth factor receptor mutant form EGFRvIII and human mesothelin, with potential
immunostimulatory and antineoplastic activities. Upon intravenous administration,
the live-attenuated Listeria monocytogenes encoding EGFRvIII-mesothelin vaccine Pemlimogene
merolisbac is taken up by antigen-presenting cells (APCs), including dendritic cells
(DCs). EGFRvIII and mesothelin are subsequently expressed by the APCs and then processed
and presented to the immune system by both major histocompatibility complex (MHC)
class I and II molecules. This activates the immune system and leads to the recruitment
and activation of cytotoxic T-lymphocytes (CTLs) against EGFRvIII- and mesothelin-expressing
tumor cells, eventually resulting in tumor cell lysis. EGFRvIII and mesothelin are
overexpressed in many types of cancer. Two genes contributing to the virulence of
Lm have been removed to minimize the risk of infection.;
UNII : S2EGO8116S;
Molecule name : ADU-214;
NCI Metathesaurus CUI : CL503062;
Origin ID : C124843;
UMLS CUI : C4086550;
Semantic type(s)
- concept_is_in_subset
- has_target
