NCIt definition : A dual-targeting bispecific antibody and T-cell engager (BiTE) co-targeting both the
human tumor-associated antigens (TAAs) cadherin-3 (CDH3; placental cadherin; P-cadherin)
and mesothelin (MSLN) on tumor cells and CD3 antigen found on T-lymphocytes, with
potential immunostimulating and antineoplastic activities. Upon administration, anti-CDH3/MSLN
BiTE antibody AMG 305 binds with specificity to tumor cells co-expressing CDH3 and
MSLN antigens and CD3 on cytotoxic T-lymphocytes (CTLs). This results in the cross-linking
of T-cells and tumor cells, and induces a cytotoxic T-lymphocyte (CTL) response against
CDH3- and MSLN-co-expressing tumor cells. CDH3 is a member of the cadherin family;
it is overexpressed in a variety of tumors and plays a role in cell adhesion, motility,
invasion, and proliferation. Mesothelin, a cell surface glycoprotein involved in cell
adhesion, is overexpressed in a variety of cancer cell types. Binding of both CDH3
and MSLN allows for increased specificity in targeting these TAAs that may be expressed
at low levels on the tumor surface while limiting activity against normal cells that
express only one of the target antigens.;
Semantic type(s)