Cadherin-3 - CISMeF

Preferred Label : Cadherin-3;

NCIt synonyms : CDH3; P-Cadherin; Placental Cadherin; Placental Calcium-Dependent Adhesion Protein; Cadherin 3;

NCIt definition : Cadherin-3 (829 aa, 91 kDa) is encoded by the human CDH3 gene. This protein is involved in calcium-dependent cell-cell adhesion.;

NCIt note : Encoded by human CDH3 Gene (CDH Family), 829-amino acid 91 kD (precursor) Placental Cadherin is a homophilic Ca(2 )-dependent cell-cell adhesion type I membrane glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Aberrant expression is observed in cervical adenocarcinomas. Hypotrichosis with juvenile macular dystrophy is caused by production of a truncated protein resulting from a homozygous nucleotide deletion.;

Details

Origin ID

C21020;

UMLS CUI

C1723700;

Currated CISMeF NLP mapping
- P-Cadherins [MeSH concept]
- P-cadherin [FMA entity]
OMIM relation
- Cadherin 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CDH3 protein, human [MeSH Supplementary Concept]
- CDH3 protein, human [MeSH concept]
- P-Cadherins [MeSH concept]
- P-cadherin [FMA entity]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CDH3 Gene [NCIt concept]
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Placenta [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Calcium Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cadherin Domain [NCIt concept]
- Cytoplasmic Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Binding [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]
is_target
- Anti-CDH3/MSLN BiTE Antibody AMG 305 [NCIt concept]
- P-cadherin Antagonist PF-03732010 [NCIt concept]
- P-cadherin Inhibitor PCA062 [NCIt concept]
- P-cadherin-targeting Agent PF-06671008 [NCIt concept]
- Yttrium Y 90 Anti-CDH3 Monoclonal Antibody FF-21101 [NCIt concept]

Keyword's position in hierarchy(ies) :

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