Preferred Label : Anti-CDH3/MMAE Antibody-drug Conjugate BC3195;
NCIt synonyms : Anti-CDH3/MMAE ADC BC3195; Anti-CDH3 Antibody-drug Conjugate BC3195; Anti-CDH3 ADC BC3195;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the human tumor-associated antigen (TAA) cadherin-3 (CDH3; placental cadherin; P-cadherin),
conjugated to the auristatin derivative and microtubule-disrupting cytotoxic agent
monomethyl auristatin E (MMAE) via a valine-citrulline (VC) peptide linker, with potential
antineoplastic activity. Upon administration of anti-CDH3/MMAE ADC BC3195, the monoclonal
antibody moiety targets and binds to CDH3 expressed on tumor cells. Upon internalization,
proteolytic cleavage of linker, and the release of MMAE, MMAE targets and binds to
tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell
cycle arrest and apoptosis in CDH3-expressing tumor cells. In addition, BC3195 is
able to induce a bystander effect on neighboring tumor cells. CDH3 is a member of
the cadherin family; it is overexpressed in a variety of tumors and plays a role in
cell adhesion, motility, invasion, and proliferation.;
Molecule name : BC 3195; BC-3195;
Origin ID : C207786;
concept_is_in_subset
- has_target
