Preferred Label : Yttrium Y 90 Anti-CDH3 Monoclonal Antibody FF-21101;
NCIt synonyms : FF-21101(90Y);
NCIt definition : A radioimmunoconjugate consisting of a chimeric monoclonal antibody targeting human
cadherin-3 (CDH3) and labeled, via the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic
acid (DOTA), with the beta-emitting radioisotope yttrium Y 90, with potential antineoplastic
activities. Upon administration, the antibody moiety of yttrium Y 90 anti-CDH3 monoclonal
antibody FF-21101 binds to CDH3 expressed on tumor cells, thereby specifically delivering
cytotoxic beta radiation to CDH3-expressing tumor cells. CDH3, also known as P-cadherin,
is a tumor-associated antigen (TAA) and member of the cadherin family; it is overexpressed
in a variety of tumors and plays a role in cell adhesion, motility, invasion, and
proliferation.;
Origin ID : C122405;
UMLS CUI : C4053526;
Semantic type(s)
- concept_is_in_subset
- has_target
