Preferred Label : Anti-mesothelin Antibody-drug Conjugate BMS-986148;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the cell surface glycoprotein mesothelin and conjugated to an as of yet undisclosed
cytotoxic drug, with potential antineoplastic activity. The monoclonal antibody moiety
of anti-mesothelin ADC BMS-986148 targets and binds to the tumor associated antigen
mesothelin. Upon internalization, the cytotoxic agent kills or prevents cellular proliferation
of mesothelin-expressing tumor cells through an as of yet undescribed mechanism of
action. Mesothelin is overexpressed by all mesotheliomas and a variety of other cancers,
while it is minimally expressed in normal tissue.;
Molecule name : BMS-986148;
Origin ID : C120303;
UMLS CUI : C3896897;
Semantic type(s)
- concept_is_in_subset
- has_target
