NCIt definition : A preparation of peripheral blood lymphocytes (PBLs) transduced with a retroviral
vector encoding a T cell chimeric antigen receptor (CAR) specific for mesothelin with
potential immunostimulatory and antineoplastic activities. After transduction, expansion
in culture, and reintroduction into the patient, the mesothelin-specific chimeric
antigen receptor-engineered PBLs bind to tumor cells expressing mesothelin. This may
stimulate the secretion of cytokines and result in cell lysis of mesothelin-expressing
cancer cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is
overexpressed in many epithelial-derived cancers.;
Semantic type(s)