Preferred Label : Anti-mesothelin CAR Vector-transduced T-lymphocytes;
NCIt synonyms : HuCART-meso; Anti-MSLN CAR-T Cells;
NCIt definition : A preparation of genetically modified T-lymphocytes transduced with a lentiviral vector
encoding a chimeric antigen receptor (CAR) specific for the human tumor-associated
antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic
activities. Upon administration, the anti-MSLN CAR vector-transduced T-lymphocytes
specifically target and kill MSLN-expressing tumor cells. MSLN, a cell surface glycoprotein
involved in cell adhesion, is overexpressed in a variety of cancer cell types.;
NCI Metathesaurus CUI : CL1792205;
Origin ID : C187372;
UMLS CUI : C5707052;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
