SS1(dsFv)-PE38 Immunotoxin

Preferred Label : SS1(dsFv)-PE38 Immunotoxin;

NCIt synonyms : SS1P; Immunotoxin, SS1(dsFv)-PE38; SS1(dsFv) PE38; SS1 dsFv-PE38 Immunotoxin;

NCIt definition : A recombinant immunotoxin consisting of the single chain anti-mesothelin monoclonal antibody SS1(dsFv) linked to Pseudomonas exotoxin PE-38. The monoclonal antibody moiety of the agent binds to cells that express mesothelin, a cell surface glycoprotein which may be overexpressed in ovarian cancer, mesotheliomas, and some squamous cell carcinomas; after internalization, the exotoxin moiety inactivates eukaryotic translation elongation factor 2, thereby disrupting tumor cell protein synthesis. (NCI04);

NSC code : 726388;

Details

Origin ID

C2609;

UMLS CUI

C1258770;

Automatic exact mappings (from CISMeF team)
- SS1(dsFv)PE38 [MeSH concept]
Currated CISMeF NLP mapping
- SS1(dsFv)PE38 [MeSH Supplementary Concept]
Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SS1(dsFv)PE38 [MeSH concept]
- SS1(dsFv)PE38 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Mesothelin [NCIt concept]

Keyword's position in hierarchy(ies) :

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