" /> SS1(dsFv)-PE38 Immunotoxin - CISMeF





Preferred Label : SS1(dsFv)-PE38 Immunotoxin;

NCIt synonyms : SS1P; Immunotoxin, SS1(dsFv)-PE38; SS1(dsFv) PE38; SS1 dsFv-PE38 Immunotoxin;

NCIt definition : A recombinant immunotoxin consisting of the single chain anti-mesothelin monoclonal antibody SS1(dsFv) linked to Pseudomonas exotoxin PE-38. The monoclonal antibody moiety of the agent binds to cells that express mesothelin, a cell surface glycoprotein which may be overexpressed in ovarian cancer, mesotheliomas, and some squamous cell carcinomas; after internalization, the exotoxin moiety inactivates eukaryotic translation elongation factor 2, thereby disrupting tumor cell protein synthesis. (NCI04);

NSC code : 726388;

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06/07/2025


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