Preferred Label : CD40L-Fc Fusion Protein MEDI5083;
NCIt related terms : MEDI-5083;
NCIt definition : A fusion protein composed of CD40 ligand (CD40L; CD154; TRAP; TNFSF5) fused to a modified
immunoglobulin (Ig) Fc fragment, with potential immunostimulating activity. Upon administration
of the CD40L-Fc fusion protein MEDI5083, the CD40L moiety specifically targets, binds
to, and activates CD40, a cell surface receptor that belongs to the tumor necrosis
factor (TNF) receptor family and is expressed on various immune cells, such as B-lymphocytes,
monocytes, and dendritic cells (DCs). Activation of CD40 induces proliferation and
activation of B-lymphocytes, shifts the induction of suppressive macrophages towards
immunostimulatory macrophages, activates monocyte-derived DCs (moDCs), and leads to
the secretion of inflammatory cytokines, which activates the immune system to induce
the proliferation and activation of cytotoxic T-lymphocytes (CTLs) against tumor cells.
Altogether, this may cause tumor cell lysis.;
UNII : IF0TRZ2MZ3;
Molecule name : MEDI 5083; MEDI-5083;
NCI Metathesaurus CUI : CL550995;
Origin ID : C148416;
UMLS CUI : C4725018;
Semantic type(s)
- concept_is_in_subset
- has_target
