Preferred Label : Tecaginlimab;
NCIt synonyms : DuoBody-CD40x4-1BB GEN1042; Anti-CD40/Anti-CD137 Bispecific Agonist Monoclonal Antibody GEN1042; Anti-CD40/Anti-4-1BB Bispecific Agonist Monoclonal Antibody GEN1042;
NCIt definition : A humanized immunoglobulin (Ig) G1, Fc-silenced, bispecific, agonistic monoclonal
antibody targeting both CD40 and 4-1BB (CD137; tumor necrosis factor receptor superfamily
member 9; TNFRSF9), with potential immunostimulatory and antineoplastic activity.
Upon administration, tecaginlimab simultaneously binds to CD40 and 4-1BB, crosslinks
CD40 and 4-1BB positive cells, induces conditional stimulation, and activates both
CD40- and 4-1BB-medicated signaling. The activation of CD40-mediated signaling triggers
the proliferation and activation of antigen-presenting cells (APCs) and activates
T-cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune
response against tumor cells. The activation of 4-1BB-mediated signaling induces cytokine
production and promotes T-cell mediated anti-tumor immune responses. CD40, a cell
surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF),
is expressed on various immune cells, such as dendritic cells (DCs), macrophages and
B-cells, and plays a key role in the activation of the immune system. 4-1BB, a surface
glycoprotein of the TNFRSF, is an inducible costimulatory receptor that plays a key
role in T-cell proliferation, survival and cytolytic activity.;
UNII : 27X2015N23;
CAS number : 2253891-70-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2253891-70-0
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : GEN-1042; BNT 312; BNT-312; GEN 1042;
NCI Metathesaurus CUI : CL972921;
Origin ID : C168604;
UMLS CUI : C5706661;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
