Preferred Label : FAPa-targeted CD40 Agonist RO7300490;
NCIt synonyms : Fibroblast Activation Protein-alpha Targeted CD40 Agonist RO7300490;
NCIt definition : A CD40 agonist that targets the inducible tumor stromal antigen fibroblast activation
protein-alpha (FAP-alpha; FAPa), with potential immunostimulatory and antineoplastic
activities. Upon administration, FAPa-targeted CD40 agonist RO7300490 targets and
binds to cell surface glycoprotein FAP which is broadly expressed on cancer-associated
fibroblasts (CAFs) in the tumor microenvironment (TME) of a variety of tumors. RO7300490
also binds to and activates CD40, a cell surface stimulatory receptor that belongs
to the tumor necrosis factor (TNF) receptor family and is expressed on various immune
cells, such as B-lymphocytes, monocytes, and dendritic cells (DCs). This crosslinks
FAP-expressing CAFs and CD40-expressing immune cells. Activation of CD40 induces proliferation
and activation of B-lymphocytes, shifts the induction of suppressive macrophages towards
immunostimulatory macrophages, activates monocyte-derived DCs (moDCs), and leads to
the secretion of inflammatory cytokines, which activates the immune system to induce
the proliferation and activation of cytotoxic T-lymphocytes (CTLs) against tumor cells.;
Molecule name : RO 7300490; RO-7300490;
NCI Metathesaurus CUI : CL1663336;
Origin ID : C180677;
UMLS CUI : C5556551;
Semantic type(s)
- concept_is_in_subset
- has_target
