NCIt definition : A humanized, agonistic monoclonal antibody targeting the B-cell surface antigen CD40,
with potential immunostimulatory and antineoplastic activities. Upon administration,
dalnicastobart targets and binds to CD40 on a variety of immune cell types. This induces
CD40-dependent signaling pathways, triggers the proliferation and activation of antigen-presenting
cells (APCs) and activates T-cells. This results in an enhanced cytotoxic T-lymphocyte
(CTL)-mediated immune response against tumor cells. CD40, a cell surface receptor
and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed
on various immune cells, such as dendritic cells (DCs), macrophages and B-cells, and
plays a key role in the activation of the immune system.;
Semantic type(s)