Monoclonal Antibody SGN-14

Preferred Label : Monoclonal Antibody SGN-14;

NCIt definition : A humanized monoclonal antibody targeting the CD40 antigen with potential antineoplastic activity. CD-40, an integral membrane protein found on the surface of B lymphocytes and member of the tumor necrosis factor receptor super-family, is highly overexpressed on the cell surface of a number of B-cell malignancies. Monoclonal antibody SGN-14 specifically binds to and inhibits CD-40, thereby inhibiting cell proliferation and inducing cell lysis via antibody-dependent cellular cytotoxicity (ADCC) in cells.;

Molecule name : SGN-14;

Details

Origin ID

C2005;

UMLS CUI

C4721904;

Currated CISMeF NLP mapping
- SGN 40 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SGN 40 [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Receptor Superfamily Member 5 [NCIt concept]

Keyword's position in hierarchy(ies) :

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