Preferred Label : Cifurtilimab;
NCIt synonyms : Anti-CD40 Monoclonal Antibody SEA-CD40;
NCIt definition : A proprietary, non-fucosylated monoclonal antibody directed against the cell surface
receptor CD40 with potential immunostimulatory and antineoplastic activities. Upon
intravenous administration, cifurtilimab binds to CD40 on a variety of immune cell
types, triggering both cellular proliferation and activation of antigen-presenting
cells (APCs), which activates B-cells and T-cells, and enhances the immune response
against tumor cells. In addition, this agent binds to the CD40 antigen present on
the surfaces of tumor cells, which induces antibody-dependent cytotoxicity (ADCC),
and eventually inhibits the proliferation of CD40-expressing tumor cells. CD40, a
stimulatory receptor and a member of the tumor necrosis factor (TNF) receptor superfamily,
is expressed on various immune cells, such as macrophages, dendritic cells and various
tumor cell types; it plays a key role in the activation of the immune system. The
non-fucosylated antibody shows increased efficacy as compared to its fucosylated counterpart.;
UNII : BY4DOG9SMH;
Molecule name : SEA-CD40; SEA CD40;
Origin ID : C121217;
UMLS CUI : C5783348;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
