Preferred Label : Anti-CD40 Monoclonal Antibody Chi Lob 7/4;
NCIt definition : An IgG1 chimeric monoclonal antibody agonist of the cell surface receptor CD40 with
potential immunostimulatory and antineoplastic activities. Upon intravenous administration,
anti-CD40 monoclonal antibody Chi Lob 7/4 binds to CD40 on a variety of immune cell
types, triggering the cellular proliferation and activation of antigen-presenting
cells (APCs), activating B cells and T cells, and enhancing the immune response; in
addition, this agent binds to the CD40 antigen present on the surfaces of some solid
tumor cells, resulting in complement-dependent cytotoxicity (CDC) and antibody-dependent
cytotoxicity (ADCC) eventually resulting in decreased tumor growth. CD40, a member
of the tumor necrosis factor (TNF) receptor superfamily, is expressed on various immune
cells, many B-cell malignancies, and many solid tumors, mediating both indirect tumor
cell death through the activation of the immune system and direct tumor cell apoptosis.;
Molecule name : Chi Lob 7/4;
NCI Metathesaurus CUI : CL435546;
Origin ID : C101366;
UMLS CUI : C3640094;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
