" /> Selicrelumab - CISMeF





Preferred Label : Selicrelumab;

NCIt synonyms : Anti-CD40 Monoclonal Antibody CP-870 893; CD40 Agonist Monoclonal Antibody CP-870,893;

NCIt definition : A human immunoglobulin G2 (IgG2) monoclonal antibody agonist of the cell surface receptor CD40, with potential immunostimulatory and antineoplastic activities. Upon administration, selicrelumab targets and binds to CD40 expressed on a variety of immune cell types. This induces CD40-dependent signaling pathways and triggers the cellular proliferation and activation of antigen-presenting cells (APCs), and activates B-cells and T-cells, resulting in an enhanced anti-tumor immune response. CD40, a cell surface receptor and member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on various immune cells and certain cancer cells; it plays a key role in the activation of the immune system.;

UNII : 0O39RGI33V;

CAS number : 1622140-49-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1622140-49-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : RO7009789; CP-870,893;

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15/05/2024


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