NCIt definition : An agonistic monoclonal antibody directed against the B-cell surface antigen CD40,
with potential antineoplastic activity. Upon administration, giloralimab binds to
CD40 on a variety of immune cell types. This induces CD40-dependent signaling pathways,
triggers the proliferation and activation of antigen-presenting cells (APCs), and
activates T-cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated
immune response against tumor cells. CD40, a cell surface receptor and member of the
tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune
cells and plays a key role in the activation of the immune system.;
UNII : W6C58X3BFH;
CAS number : 2226292-20-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2226292-20-0
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G-SRS /a ;
Semantic type(s)