NCIt definition : An agonistic monoclonal antibody directed against the B-cell surface antigen CD40,
with potential antineoplastic activity. Upon administration, giloralimab binds to
CD40 on a variety of immune cell types. This induces CD40-dependent signaling pathways,
triggers the proliferation and activation of antigen-presenting cells (APCs), and
activates T-cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated
immune response against tumor cells. CD40, a cell surface receptor and member of the
tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune
cells and plays a key role in the activation of the immune system.;
Semantic type(s)