Recombinant CD40-Ligand

Preferred Label : Recombinant CD40-Ligand;

NCIt synonyms : TRAP Ligand; gp39; T-BAM; CD40L; T-Cell Antigen gp39; TNF-Related Activation Protein; rhu CD40L; CD154 antigen; Therapeutic CD40-Ligand;

NCIt definition : A recombinant therapeutic agent which is chemically identical to or similar to CD40-ligand. CD40-ligand, also known as CD40L/TRAP and CD154, is a type II membrane protein which binds to CD40, a cell surface receptor that belongs to the tumor necrosis factor receptor family; CD40 is expressed on B lymphocytes, monocytes, dendritic cells (DC), hematopoietic progenitors, endothelial cells and epithelial cells. Recombinant CD40-ligand may be used to activate DC ex vivo via CD40 binding; CD40-ligand-activated DC may provide or augment a protective antitumor immunity when administered in dendritic cell cancer vaccines. (NCI04);

CAS number : 147205-72-9;

NSC code : 696600;

Details

Origin ID

C1437;

UMLS CUI

C1527003;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- T-Lymphocyte [NCIt concept]
chemical_or_drug_affects_gene_product
- Tumor Necrosis Factor Receptor Superfamily Member 5 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immune Cell Activation Process [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Autologous Dendritic Cells/CD40-Ligand [NCIt concept]
- Autologous Dendritic Cells/Candida Albicans Skin Test Reagent/CD40-Ligand/gp100 Antigen/Interferon Gamma/Interleukin-4/MART-1 Antigen/Sargramostim/Tyrosinase Peptide [NCIt concept]
- Autologous Tumor Cell Vaccine/CD40-Ligand/Interleukin-2 Gene [NCIt concept]
- CD40-Ligand/flt3 Ligand [NCIt concept]

Keyword's position in hierarchy(ies) :

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