Preferred Label : Enadenotucirev-expressing Anti-CD40 Agonistic Monoclonal Antibody NG-350A;
NCIt synonyms : Oncolytic Adenoviral Vector-expressing Anti-CD40 Agonistic Antibody NG-350A; Oncolytic Adenoviral Vector Expressing Anti-CD40 Antibody NG-350A;
NCIt definition : An oncolytic adenoviral vector, enadenotucirev (EnAd), that expresses a full-length
agonistic anti-CD40 monoclonal antibody, with potential immunomodulating and antineoplastic
activities. Upon intratumoral administration of NG-350A, enadenotucirev specifically
infects and replicates in tumor cells and not in normal, noncancerous tissue, and
selectively expresses the agonistic anti-CD40 antibody. The locally expressed anti-CD40
antibody targets and binds to CD40 on a variety of immune cells, including B-cells,
T-cells and dendritic cells (DCs) in the tumor microenvironment (TME). This induces
CD40-dependent signaling pathways, which activates these immune cells and induces
a cytotoxic T-lymphocyte (CTL)-mediated antitumor immune response and leads to tumor
cell death. CD40, a cell surface receptor and member of the tumor necrosis factor
receptor superfamily (TNFRSF), is expressed on various immune cells and plays a key
role in the activation of the immune system.;
Molecule name : NG-350A; NG 350A;
NCI Metathesaurus CUI : CL951598;
Origin ID : C159599;
UMLS CUI : C5204560;
Semantic type(s)
- concept_is_in_subset
- has_target
