Preferred Label : Anti-EpCAM/Anti-CD40 Bispecific Antibody KK2269;
NCIt synonyms : EpCAM x CD40 Bispecific Antibody KK2269; Anti-CD40/Anti-EpCAM Bispecific Antibody KK2269; EpCAM-targeted CD40 Agonist KK2269; Anti-EpCAM/CD40 Bispecific Antibody KK2269;
NCIt definition : A bispecific antibody directed against both the tumor-associated antigen (TAA) human
epithelial cell adhesion molecule (Ep-CAM; EpCAM; CD326) and the cell surface receptor
CD40, with potential immunostimulatory and antineoplastic activities. Upon administration
of anti-EpCAM/anti-CD40 bispecific antibody KK2269, the anti-EpCAM moiety targets
and binds to EpCAM expressed on tumor cells, and the agonistic anti-CD40 moiety targets
and binds to various CD40-expressing immune cells in the tumor microenvironment (TME).
This induces EpCAM-dependent activation of CD40-mediated signaling pathways, and triggers
the proliferation and activation of antigen-presenting cells (APCs) and activates
T-cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune
response against tumor cells. CD40, a stimulatory receptor and a member of the tumor
necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells,
such as macrophages, B-lymphocytes, and dendritic cells (DCs); it plays a key role
in the activation of the immune system. EpCAM, a cell surface protein upregulated
on many tumor cell types, promotes the proliferation, migration and invasiveness of
tumor cells.;
Molecule name : KK-2269; KK 2269;
Origin ID : C209758;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
